Hydrochloric Acid → 4-(Dibenzylamino)butanoic acid

HRID 473604노트

반응식

HRID 473604 반응식
C([O:3][C:4](=[O:23])[CH2:5][CH2:6][CH2:7][N:8]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)C.Cl>C1COCC1>[CH2:16]([N:8]([CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[CH2:7][CH2:6][CH2:5][C:4]([OH:23])=[O:3])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 13929784Ethyl 4-(Dibenzylamino)butanoate

생성물 1

HCID 146277764-(Dibenzylamino)butanoic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 500 mg (1.6 mmol, 1 equiv.) of 4-dibenzylamino-butyric acid ethyl ester in 1 ml of THF was added 4 ml of HCl 2N and the resulting mixture was stirred for 48 hours. After decantation and separation, the aqueous layer was extracted twice by ethyl acetate. The pH was fixed to 5 using solid sodium carbonate and the aqueous layer was extracted by dichloromethane. The dichloromethane layer was dried over sodium sulphate, evaporated and used without further purification.

후처리

  1. customAfter decantation and separation
  2. extractionthe aqueous layer was extracted twice by ethyl acetate
  3. extractionthe aqueous layer was extracted by dichloromethane
  4. dry with materialThe dichloromethane layer was dried over sodium sulphate
  5. customevaporated
  6. customused without further purification

출처 및 근거

ORD 기록
ord-592d667beef04324878fc26cb879470e
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637496B2

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