Sodium Hydroxide → 7,9-dichloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid

HRID 47362

반응식

HRID 47362 반응식
C([O:3][C:4]([CH:6]1[CH:15]2[CH2:16][CH:17]=[CH:18][CH:14]2[C:13]2[C:12]([Cl:19])=[CH:11][C:10]([Cl:20])=[CH:9][C:8]=2[NH:7]1)=[O:5])C.[OH-].[Na+]>C(O)C>[Cl:20][C:10]1[CH:11]=[C:12]([Cl:19])[C:13]2[CH:14]3[CH:18]=[CH:17][CH2:16][CH:15]3[CH:6]([C:4]([OH:5])=[O:3])[NH:7][C:8]=2[CH:9]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 98832257,9-dichloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid ethyl ester

생성물 1

HCID 29147727,9-dichloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Compound 1 was saponified with 1.0 ml sodium hydroxide solution (6N, water) in 20.0 ml ethanol. The ethanolic solution was concentrated to small volume on a rotary evaporator, the residue was taken up in water, reacted with 6N HCl and the aqueous solution extracted three times over ether. The organic phase was washed neutral with water, dried over magnesium sulphate and concentrated to a reduced volume on a rotary evaporator.

후처리

  1. concentrationThe ethanolic solution was concentrated to small volume on a rotary evaporator
  2. customreacted with 6N HCl
  3. extractionthe aqueous solution extracted three times over ether
  4. washThe organic phase was washed neutral with water
  5. dry with materialdried over magnesium sulphate
  6. concentrationconcentrated to a reduced volume on a rotary evaporator

출처 및 근거

ORD 기록
ord-cf3b603d4cea4b518d3f7d1107febe51
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699877B2

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