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3,4-dihydro-2H-pyran → N-[4-[[3-(3,4-Dihydro-2H-pyran-2-yl)-2-pyridinyl]oxy]phenyl]-2-pyridinamine

HRID 473659
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인쇄 미리보기

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HRID 473659 반응식
Cl.Br[C:3]1[C:4]([O:9][C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)=[CH:12][CH:11]=2)=[N:5][CH:6]=[CH:7][CH:8]=1.C1(N(C)C2CCCCC2)CCCCC1.[O:37]1[CH:42]=[CH:41][CH2:40][CH2:39][CH2:38]1>[Pd].C(P(C(C)(C)C)C(C)(C)C)(C)(C)C.C(P(C(C)(C)C)C(C)(C)C)(C)(C)C.O1CCOCC1>[O:37]1[CH:38]=[CH:39][CH2:40][CH2:41][CH:42]1[C:3]1[C:4]([O:9][C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)=[CH:12][CH:11]=2)=[N:5][CH:6]=[CH:7][CH:8]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 80803,4-dihydro-2H-pyranHCID 24210N-Methyl dicyclohexylamineHCID 67425919N-(4-(3-Bromopyridin-2-yloxy)phenyl)pyridin-2-amine hydrochloride

생성물 1

HCID 59374292N-[4-[[3-(3,4-Dihydro-2H-pyran-2-yl)-2-pyridinyl]oxy]phenyl]-2-pyridinamine

시약·촉매·용매 2

HCID 2734558Bis(tri-tert-butylphosphine)palladium(0)촉매
HCID 31275
1,4-Dioxane
용매

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온도
105 °C

실험 절차

To a 25 mL microwave vial was added Bis(tri-tert-butylphosphine) palladium (0) (101 mg, 0.198 mmol) and N-(4-(3-bromopyridin-2-yloxy)phenyl)pyridin-2-amine hydrochloride (750 mg, 1.981 mmol) before evacuating and backfilling with nitrogen (2×). After addition of Dioxane (5.659 ml), N-cyclohexyl-N-methylcyclohexanamine (0.840 ml, 3.96 mmol), and 3,4-dihydro-2H-pyran (666 mg, 7.92 mmol) was added and the mixture was heated to 105° C. Following complete consumption of the starting material, the reaction mixture was cooled to room temperature and the volatiles were removed under reduced pressure. Following silica gel chromatography, the title compound was obtained as a racemic mixture. MS (ESI, pos. ion) m/z: 346.0. IC50 (uM) 0.064.

후처리

  1. custombefore evacuating
  2. additionwas added
  3. customconsumption of the starting material
  4. temperaturethe reaction mixture was cooled to room temperature
  5. customthe volatiles were removed under reduced pressure

출처 및 근거

ORD 기록
ord-c3626ddc923647bab10de00cd13c2f77
출처 데이터셋
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08637500B2

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