Trifluoroacetic acid → 5,7-dichloro-4-(2,4-dimethylphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

HRID 47376노트

반응식

HRID 47376 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[CH2:10]([C:12](=O)[C:13]([O-:15])=[O:14])[CH3:11].[CH3:17][C:18]1[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:19]=1C=C.FC(F)(F)C(O)=O.[OH-].[Na+]>C(#N)C.C(O)C>[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:4]2[C:3]=1[CH:11]([C:19]1[CH:22]=[CH:23][C:24]([CH3:26])=[CH:25][C:18]=1[CH3:17])[CH2:10][CH:12]([C:13]([OH:15])=[O:14])[NH:5]2

참가 물질

8

반응물 5

HCID 6422Trifluoroacetic acidHCID 122813,5-DichloroanilineHCID 14798Sodium HydroxideHCID 166942,4-DimethylstyreneHCID 35932772-Ketobutyrate

생성물 1

HCID 99463775,7-dichloro-4-(2,4-dimethylphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6342Acetonitrile용매

실험 절차

Compound 22 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 2,4-dimethylstyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.

출처 및 근거

ORD 기록
ord-a0336ceea30a42ed8d5a3bc52c698fd4
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699877B2

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