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1,1-dimethylethyl 7-[6-(1H-imidazol-2-yl)pyridin-3-yl]-2,3-dihydro-1,4-benzoxazepin-4(5H)-carboxylate → 7-[6-(1H-imidazol-2-yl)pyridin-3-yl]-2,3,4,5-tetrahydro-1,4-benzoxazepine

HRID 473912
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HRID 473912 반응식
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[N:11]=[CH:10][C:9]([C:12]2[CH:13]=[CH:14][C:15]3[O:21][CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][C:16]=3[CH:29]=2)=[CH:8][CH:7]=1>CO.Cl.O1CCOCC1>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[N:11]=[CH:10][C:9]([C:12]2[CH:13]=[CH:14][C:15]3[O:21][CH2:20][CH2:19][NH:18][CH2:17][C:16]=3[CH:29]=2)=[CH:8][CH:7]=1
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참가 물질

5

반응물 1

HCID 696751261,1-dimethylethyl 7-[6-(1H-imidazol-2-yl)pyridin-3-yl]-2,3-dihydro-1,4-benzoxazepin-4(5H)-carboxylate

생성물 1

HCID 675137447-[6-(1H-imidazol-2-yl)pyridin-3-yl]-2,3,4,5-tetrahydro-1,4-benzoxazepine

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

A solution of 1,1-dimethylethyl 7-[6-(1H-imidazol-2-yl)pyridin-3-yl]-2,3-dihydro-1,4-benzoxazepin-4(5H)-carboxylate (50 mg, 0.13 mmol) in a mixture of methanol (2 mL) and 4N hydrochloric acid in dioxane (2 mL) was refluxed for 5 min. After cooling to room temperature and the reaction mixture was concentrated. The residue was then concentrated from chloroform (3×) and dried to give crude 7-[6-(1H-imidazol-2-yl)pyridin-3-yl]-2,3,4,5-tetrahydro-1,4-benzoxazepine.

후처리

  1. temperaturewas refluxed for 5 min
  2. concentrationthe reaction mixture was concentrated
  3. concentrationThe residue was then concentrated from chloroform (3×)
  4. customdried

출처 및 근거

ORD 기록
ord-58ce706d562f4949a9cc2e6da2b25702
출처 데이터셋
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08637499B2

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