Trifluoroacetic acid → 5,7-Dichloro-3-methyl-4-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester

HRID 47396

반응식

HRID 47396 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[CH2:10](C(=O)C([O-])=O)[CH3:11].[CH3:17][CH:18]=[CH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.F[C:27](F)(F)[C:28]([OH:30])=[O:29]>C(#N)C>[CH2:10]([O:30][C:28]([CH:27]1[CH:18]([CH3:17])[CH:19]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:3]2[C:4](=[CH:6][C:7]([Cl:9])=[CH:8][C:2]=2[Cl:1])[NH:5]1)=[O:29])[CH3:11]

참가 물질

6

반응물 4

HCID 6422Trifluoroacetic acidHCID 122813,5-DichloroanilineHCID 12500beta-MethylstyreneHCID 35932772-Ketobutyrate

생성물 1

HCID 102922165,7-Dichloro-3-methyl-4-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Compound 42 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol β-methylstyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.

출처 및 근거

ORD 기록
ord-834b71bf6a504cfa994a60174df21e7d
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699877B2

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