Ethyl Acetoacetate → HCID 178428858, 화합물

반응식

[F:1][C:2]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:3]=1[NH2:4].[C:10](OCC)(=[O:15])[CH2:11][C:12]([CH3:14])=O>>[OH:15][C:10]1[C:5]2[C:3](=[C:2]([F:1])[CH:8]=[CH:7][C:6]=2[F:9])[N:4]=[C:12]([CH3:14])[CH:11]=1

참가 물질

반응물 2

HCID 8868Ethyl Acetoacetate

HCID 677752,5-Difluoroaniline

생성물 1

HCID 178428858HCID 178428858, 화합물

반응 조건

온도: 180 °C

실험 절차

A mixture of 2,5-difluoroaniline (10.0 g), ethyl acetoaceate (9.85 ml) and polyphosphoric acid (62 ml) were heated with stirring at 180° C. for 5 h. The mixture was cooled to room temperature and neutralised with dilute NH4OH/ice. The title compound precipitated and was separated by filtration to give compound identical spectroscopically with a sample prepared by the two stage process described above.

후처리

temperaturewere heated
customThe title compound precipitated
customwas separated by filtration
customto give compound identical spectroscopically with a sample
customprepared by the two stage process

출처 및 근거

ORD 기록: ord-8b17e9aa18ed46d68e546c4fd480db74
출처 데이터셋: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06699879B1

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