Sodium Hydroxide → 8-Fluoro-2-methoxy-4-quinolinecarboxylic acid

HRID 47432노트

반응식

HRID 47432 반응식
C[O:2][C:3]([C:5]1[C:14]2[C:9](=[C:10]([F:15])[CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([O:16][CH3:17])[CH:6]=1)=[O:4].[OH-].[Na+]>CO>[F:15][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:9]=1[N:8]=[C:7]([O:16][CH3:17])[CH:6]=[C:5]2[C:3]([OH:4])=[O:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 544876468-Fluoro-2-methoxyquinoline-4-carboxylic Acid Methyl Ester

생성물 1

HCID 227451438-Fluoro-2-methoxy-4-quinolinecarboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

8-Fluoro-2-methoxyquinoline-4-carboxylic acid methyl ester (0.1 82 g) in methanol (10 ml) containing 2N sodium hydroxide (0.41 ml) was stirred at room temperature for 16 h. Solvent was removed at reduced pressure, dissolved in water, and adjusted to pH2 with 2N hydrochloric acid. The precipitated title compound (0.155 g) was collected by filtration and dried. m/z (API−): 222 (MH+). 1H NMR δ: 4.02 (3H, s), 7.44-7.62 (3H, m), 8.31 (1H, d).

후처리

  1. customSolvent was removed at reduced pressure
  2. dissolutiondissolved in water
  3. customThe precipitated title compound (0.155 g)
  4. filtrationwas collected by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-99e2d3b1335843f0a3515c01d591ba7d
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699879B1

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