Hydrochloric Acid → HCID 66763587, 화합물

HRID 474383노트

반응식

HRID 474383 반응식
[CH3:1][O:2][CH2:3][CH2:4][CH:5]([NH:15]C(=O)OC(C)(C)C)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1.Cl>CO>[CH3:1][O:2][CH2:3][CH2:4][CH:5]([NH2:15])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68096871HCID 68096871, 화합물

생성물 1

HCID 66763587HCID 66763587, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of tert-butyl [3-methoxy-1-(3-nitrophenyl)propyl]carbamate (1.5 g; 4.83 mmol; 1.00 eq.) in MeOH (2 mL) was added hydrogen chloride (12.08 ml; 4.00 M; 48.33 mmol; 10.00 eq.). The mixture was stirred for 2 h. After removal of the solvent, the residue was diluted with EtOAc, washed with K2CO3 solution, dried and concentrated. The crude product (1.0 g) was used as such for the next reaction without purification. LCMS [211 (M+1)].

후처리

  1. customAfter removal of the solvent
  2. additionthe residue was diluted with EtOAc
  3. washwashed with K2CO3 solution
  4. customdried
  5. concentrationconcentrated
  6. customsuch for the next reaction
  7. customwithout purification

출처 및 근거

ORD 기록
ord-d1426ffea9494f66b15f8bd7819bad88
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637532B2

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