Sodium Dithionite → 4-Methoxy-3-methylsulfanylmethyl-phenylamine
반응식
S(S([O-])=O)([O-])=O.[Na+].[Na+].[CH3:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][C:12]=1[CH2:20][S:21][CH3:22].C(=O)([O-])O.[Na+]>CO.O>[CH3:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=1[CH2:20][S:21][CH3:22]참가 물질
5
실험 절차
Sodium dithionite (3.264 g) was added to a solution of 1-methoxy-2-methylsulfanylmethyl-4-nitro-benzene (0.8 g), and sodium hydrogen carbonate (1.57 g) in methanol:water (1:1, 200 ml) and stirred at room temperature for 16 h. Solvent was removed at reduced pressure, the residue partitioned between water and ethyl acetate, the organic phase separated, washed with brine dried (Na2SO4) and solvent removed at reduced pressure to give the title compound (0.23 g) as a brown oil. m/z (API+): 184 (MH+).
후처리
- customSolvent was removed at reduced pressure
- customthe residue partitioned between water and ethyl acetate
- customthe organic phase separated
- washwashed with brine
- dry with materialdried (Na2SO4) and solvent
- customremoved at reduced pressure
출처 및 근거
- ORD 기록
- ord-7eb1f9319b0a402c825caf499aa87c8f
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06699879B1
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