N-(3-Cyano-phenyl)-4-methoxy-N-methyl-benzamide → N-(3-Aminomethyl-phenyl)-4-methoxy-N-methyl-benzamide

HRID 474480노트

반응식

HRID 474480 반응식
[C:1]([C:3]1[CH:4]=[C:5]([N:9]([CH3:20])[C:10](=[O:19])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2]>N.CO.C1COCC1.[Ni]>[NH2:2][CH2:1][C:3]1[CH:4]=[C:5]([N:9]([CH3:20])[C:10](=[O:19])[C:11]2[CH:12]=[CH:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

6

반응물 1

HCID 47407961N-(3-Cyano-phenyl)-4-methoxy-N-methyl-benzamide

생성물 1

HCID 62970261N-(3-Aminomethyl-phenyl)-4-methoxy-N-methyl-benzamide

시약·촉매·용매 4

HCID 935Nickel촉매HCID 222Ammonia용매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

450 mg (1.7 mmol) N-(3-Cyano-phenyl)-4-methoxy-N-methyl-benzamide were dissolved in 10 ml NH3 in methanol (10%) and 10 ml THF. 500 mg Sponge nickel catalyst were added and the mixture was hydrogenated for 14 h at 5 bar pressure. The mixture was filtered and the filtrate was evaporated.

후처리

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-a5ed7ae50dde444c846963eb48713a28
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637532B2

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