Potassium Carbonate → 4-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}-3,5-difluorobenzaldehyde

HRID 474588

반응식

HRID 474588 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[C:9]([F:12])([F:11])[F:10].[F:13][C:14]1[CH:15]=[C:16]([CH:19]=[C:20]([F:23])[C:21]=1F)[CH:17]=[O:18].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:21]2[C:14]([F:13])=[CH:15][C:16]([CH:17]=[O:18])=[CH:19][C:20]=2[F:23])=[CH:4][C:3]=1[C:9]([F:10])([F:11])[F:12]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 805204-Chloro-3-(trifluoromethyl)phenolHCID 27769543,4,5-Trifluorobenzaldehyde

생성물 1

HCID 866661934-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}-3,5-difluorobenzaldehyde수율 79.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

The mixture of 4-chloro-3-(trifluoromethyl)phenol (3.4 g, 17.30 mmol), 3,4,5-trifluorobenzaldehyde (2.7 g, 16.87 mmol) and K2CO3 (2.80 g, 20.24 mmol) in DMF was heated with a microwave reactor at 60° C. for 1 h. Purification via a flash column chromatography then afforded the title compound (4.5 g, 79% yield). LCMS: rt=3.88 min, [M+H+]=337

후처리

  1. customPurification via a flash column chromatography

출처 및 근거

ORD 기록
ord-da3d57a365b14ac3adad97c1f06f9fd7
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637536B2

연결된 노트

불러오는 중…