Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 474588생성일: 2026년 10월 26일
Potassium Carbonate → 4-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}-3,5-difluorobenzaldehyde
https://huagongshe.com/reaction/474588
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Chloro-3-(trifluoromethyl)phenol | HCID 80520 | — |
| 반응물 | 3,4,5-Trifluorobenzaldehyde | HCID 2776954 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}-3,5-difluorobenzaldehyde | HCID 86666193 | 79.2% |
반응 단계
The mixture of 4-chloro-3-(trifluoromethyl)phenol (3.4 g, 17.30 mmol), 3,4,5-trifluorobenzaldehyde (2.7 g, 16.87 mmol) and K2CO3 (2.80 g, 20.24 mmol) in DMF was heated with a microwave reactor at 60° C. for 1 h. Purification via a flash column chromatography then afforded the title compound (4.5 g, 79% yield). LCMS: rt=3.88 min, [M+H+]=337
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08637536B2 |
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| 출처 데이터셋 | uspto-grants-2014_01 |
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| ORD ID | ord-da3d57a365b14ac3adad97c1f06f9fd7 |
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| 출처 메모 | uspto-grants-2014_01 |
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