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Tetrahydrofuran → 1-Chloro-2-(trifluoromethyl)-4-(4-vinylphenoxy)benzene

HRID 474635
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인쇄 미리보기

반응식

HRID 474635 반응식
[H-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=2)=[CH:6][C:5]=1[C:19]([F:22])([F:21])[F:20].[CH2:23]1COCC1>[Br-].C[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:18]=[CH:17][C:14]([CH:15]=[CH2:23])=[CH:13][CH:12]=2)=[CH:6][C:5]=1[C:19]([F:22])([F:21])[F:20]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8028Tetrahydrofuran2회HCID 24758Sodium hydrideHCID 866661874-(4-Chloro-3-(trifluoromethyl)phenoxy)benzaldehyde

생성물 1

HCID 668258371-Chloro-2-(trifluoromethyl)-4-(4-vinylphenoxy)benzene수율 86%

시약·촉매·용매 1

HCID 74505Methyltriphenyliphosphonium bromide촉매

반응 조건

온도
0 °C

실험 절차

To a solution of methyltriphenylphosphonium bromide (5.99 g, 16.76 mmol) and NaH (1.397 g, 34.9 mmol) in THF (50 mL) was added a solution of 4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}benzaldehyde (4.2 g, 13.97 mmol) in THF (50 mL) under nitrogen at 0° C. The reaction mixture was stirred at 0° C. for 0.5 h, then at room temperature overnight. Purification via flash chromatography then afforded the title compound (3.6 g, 12.05 mmol, 86% yield).

후처리

  1. customat room temperature
  2. customovernight
  3. customPurification via flash chromatography

출처 및 근거

ORD 기록
ord-f79146b86d4b4cef8e2be5932ebd0028
출처 데이터셋
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08637536B2

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