Potassium Acetate → HCID 178437180, 화합물

HRID 474796노트

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HRID 474796 반응식
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:4]=[C:5]([CH:18]=[CH:19][CH:20]=1)[O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][C:15](=[NH:17])[NH2:16])=[CH:9][CH:8]=1.[OH:23][CH:24]=[C:25]([CH2:30][CH3:31])[C:26](OC)=O.C([O-])(=O)C.[K+]>C1COCC1>[CH2:30]([C:25]1[C:24](=[O:23])[N:17]=[C:15]([CH2:14][CH2:13][C:10]2[CH:9]=[CH:8][C:7]([O:6][C:5]3[CH:18]=[CH:19][CH:20]=[C:3]([C:2]([F:21])([F:22])[F:1])[CH:4]=3)=[CH:12][CH:11]=2)[NH:16][CH:26]=1)[CH3:31]

참가 물질

5

반응물 3

HCID 517044Potassium AcetateHCID 677738853-(4-(3-(Trifluoromethyl)phenoxy)phenyl)propanimidamideHCID 71370995Methyl 2-(hydroxymethylidene)butanoate

생성물 1

HCID 178437180HCID 178437180, 화합물수율 16.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
100 °C

실험 절차

To a solution of 3-(4-(3-(trifluoromethyl)phenoxy)phenyl)propanimidamide (200 mg, 0.580 mmol) in THF (4 mL) were added methyl 2-(hydroxymethylene)butanoate (151 mg, 0.580 mmol) and potassium acetate (171 mg, 1.740 mmol). The mixture was stirred with a microwave condition at 100° C. for 1 h under nitrogen. The reaction mixture was cooled to room temperature; the solvent was removed in vacuo. The residue was purified MDAP to afford the title compound (36.7 mg, 16.29% yield) as a white solid. LCMS: rt=1.67 min, [M+H+]=389.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customthe solvent was removed in vacuo
  3. customThe residue was purified MDAP

출처 및 근거

ORD 기록
ord-e2421dada42b4688a5accd81a68d7489
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637536B2

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