Potassium Acetate → HCID 178494124, 화합물

HRID 474798노트

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HRID 474798 반응식
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:4]=[C:5]([CH:18]=[CH:19][CH:20]=1)[O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][C:15](=[NH:17])[NH2:16])=[CH:9][CH:8]=1.[OH:23][CH:24]=[C:25]([CH2:30][C:31]1[CH:32]=[N:33][C:34]([O:37][CH3:38])=[N:35][CH:36]=1)[C:26](OC)=O.C([O-])(=O)C.[K+]>C1(C)C=CC=CC=1>[CH3:38][O:37][C:34]1[N:33]=[CH:32][C:31]([CH2:30][C:25]2[C:24](=[O:23])[N:17]=[C:15]([CH2:14][CH2:13][C:10]3[CH:9]=[CH:8][C:7]([O:6][C:5]4[CH:18]=[CH:19][CH:20]=[C:3]([C:2]([F:21])([F:22])[F:1])[CH:4]=4)=[CH:12][CH:11]=3)[NH:16][CH:26]=2)=[CH:36][N:35]=1

참가 물질

5

반응물 3

HCID 517044Potassium AcetateHCID 67773588Methyl 3-hydroxy-2-((2-methoxypyrimidin-5-yl)methyl)acrylateHCID 677738853-(4-(3-(Trifluoromethyl)phenoxy)phenyl)propanimidamide

생성물 1

HCID 178494124HCID 178494124, 화합물수율 64.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

The same procedure as E38 from a mixture of 3-(4-(3-(trifluoromethyl) phenoxy)phenyl)propanimidamide (200 mg, 0.580 mmol), methyl 3-hydroxy-2-((2-methoxypyrimidin-5-yl)methyl)acrylate (130 mg, 0.580 mmol) and potassium acetate (171 mg, 1.740 mmol) in toluene (10 mL) to afford the title compound (180 mg, 61.1% yield) as a yellow solid. LCMS: rt=8.88 min, [M+H+]=483.

출처 및 근거

ORD 기록
ord-d5902071cc3f416180dab06f671783f5
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637536B2

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