Diisopropylethylamine → HCID 178494154, 화합물

HRID 474826노트

반응식

HRID 474826 반응식
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)=[C:5]([C:20]([F:23])([F:22])[F:21])[CH:4]=1.[CH3:24][O:25][C:26]1[N:31]=[CH:30][C:29]([CH2:32][C:33]2[C:34](=[O:40])[NH:35][C:36](=[S:39])[NH:37][CH:38]=2)=[CH:28][N:27]=1.CCN(C(C)C)C(C)C>ClCCCl>[CH3:24][O:25][C:26]1[N:27]=[CH:28][C:29]([CH2:32][C:33]2[C:34](=[O:40])[N:35]=[C:36]([S:39][CH2:2][C:3]3[CH:8]=[CH:7][C:6]([O:9][C:10]4[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=4)=[C:5]([C:20]([F:23])([F:22])[F:21])[CH:4]=3)[NH:37][CH:38]=2)=[CH:30][N:31]=1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 219362445-(2-Methoxypyrimidin-5-ylmethyl)-2-thiouracilHCID 866662074-(Chloromethyl)-2-(trifluoromethyl)-1-{[3-(trifluoromethyl)phenyl]oxy}benzene

생성물 1

HCID 178494154HCID 178494154, 화합물수율 4.4%

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

The same procedure as E63 from 4-(chloromethyl)-2-(trifluoromethyl)-1-{[3-(trifluoromethyl)phenyl]oxy}benzene (425 mg, 1.199 mmol), 5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (200 mg, 0.799 mmol) and DIPEA (0.279 mL, 1.598 mmol) in DCE (3.0 mL), except that the reaction time was prolonged to 1.5 h, to afford the title compound (20 mg, 4.40% yield). LCMS: rt=3.66 min, [M+H+]=569

출처 및 근거

ORD 기록
ord-99e18561140842cdbbc2f61e6da1cb2e
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637536B2

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