1,4-Dibromobenzene → Methyl 2-(4-(4-bromophenyl)piperazin-1-yl)acetate

온도

85 °C

In a reaction vial, 1,4-dibromobenzene (0.373 g, 1.58 mmol), methyl 2-(piperazin-1-yl)acetate (0.100 g, 0.63 mmol), CS2CO3 (0.309 g, 0.95 mmol), and BINAP (0.024 g, 0.04 mmol) were taken up in 1,4-dioxane (1.5 ml). Argon was bubbled through the solution for 1 minute. Pd2(dba)3 (0.012 g, 0.01 mmol) was added, followed by additional purging with argon. The vial was capped and placed on the heater-shaker. The reaction was stirred (450 rpm) at 100 °C overnight. LC/MS at this point did not indicate any formation of the dp. Experiment not progressed.

ORD 기록

ord-cf737b8f3d9340aca6130b04f75e7c21

출처 데이터셋

750 AstraZeneca ELN dataset

원본 링크

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