HCID 58093434, 화합물 → HCID 178517723, 화합물

HRID 475001노트

반응식

HRID 475001 반응식
C[O:2][C:3]1[N:8]=[C:7]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][N:4]=1>Cl>[CH2:9]([C:7]1[CH:6]=[CH:5][NH:4][C:3](=[O:2])[N:8]=1)[CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

3

반응물 1

HCID 58093434HCID 58093434, 화합물

생성물 1

HCID 178517723HCID 178517723, 화합물수율 74%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 2-methoxy-4-phenethylpyrimidine (0.50 g, 2.3 mmol) in concentrated HCl (4.0 mL) was heated under reflux for 16 h. The reaction solution was cooled to room temperature and filtered. The filter cake was washed with water and dried under reduced pressure to give the title compound (0.34 g, 74%) as an off-white solid: 1H NMR (500 MHz, CD3OD) δ 8.52 (d, J=6.5 Hz, 1H), 7.33-7.24 (m, 5H), 6.78 (d, J=6.0 Hz, 1H), 3.12-3.07 (m, 4H).

후처리

  1. temperatureunder reflux for 16 h
  2. filtrationfiltered
  3. washThe filter cake was washed with water
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-ebb1cb2438c042898a0f2eef58fd6b60
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637501B2

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