3,5-Di-tert-butyl-4-hydroxybenzoyl chloride → N1-[2-(4-amino-2-butyl 1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]-3,5-di-(1,1-dimethylethyl)-4-hydroxybenzamide

HRID 47505

반응식

HRID 47505 반응식
[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:13]=1[OH:14])[C:8](Cl)=[O:9])([CH3:4])[CH3:3].[NH2:19][C:20]1[C:29]2[N:30]=[C:31]([CH2:36][CH2:37][CH2:38][CH3:39])[N:32]([CH2:33][CH2:34][NH2:35])[C:28]=2[C:27]2[N:26]=[CH:25][CH:24]=[CH:23][C:22]=2[N:21]=1>>[NH2:19][C:20]1[C:29]2[N:30]=[C:31]([CH2:36][CH2:37][CH2:38][CH3:39])[N:32]([CH2:33][CH2:34][NH:35][C:8](=[O:9])[C:7]3[CH:6]=[C:5]([C:2]([CH3:4])([CH3:3])[CH3:1])[C:13]([OH:14])=[C:12]([C:15]([CH3:18])([CH3:17])[CH3:16])[CH:11]=3)[C:28]=2[C:27]2[N:26]=[CH:25][CH:24]=[CH:23][C:22]=2[N:21]=1

참가 물질

3

반응물 2

HCID 37871873,5-Di-tert-butyl-4-hydroxybenzoyl chlorideHCID 219460272-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethaneamine

생성물 1

HCID 12112191N1-[2-(4-amino-2-butyl 1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]-3,5-di-(1,1-dimethylethyl)-4-hydroxybenzamide수율 56.9%

실험 절차

Using the general method of Example 92, 3,5-di-(1,1 dimethylethyl)-4-hydroxybenzoyl chloride (0.47 g, 1.7 mmol) was reacted with 2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethaneamine (0.5 g, 1.7 mmol) to provide 0.5 g of N1-[2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]-3,5-di-(1,1-dimethylethyl) -4-hydroxybenzamide as a white powder, m.p. 248-250° C. Analysis: Calculated for C30H40N6O2: %C, 69.74; %H, 7.80; %N, 16.27. Found: %C, 69.65%H, 7.69; %N, 16.42. HRMS (EI) calcd for C30H40N6O2 (M+) 516.3212 found 516.3226

출처 및 근거

ORD 기록
ord-19bf6bf51d18408db2f50571ebc95467
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699878B2

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