Hydroxyamine hydrochloride → HCID 136336869, 화합물

HRID 475167노트

반응식

HRID 475167 반응식
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH3:11])=[C:4]([C:12](=O)[CH3:13])[CH:3]=1.Cl.[NH2:16][OH:17].CC([O-])=O.[Na+]>CCO>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH3:11])=[C:4]([C:12](=[N:16][OH:17])[CH3:13])[CH:3]=1

참가 물질

5

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 86694714HCID 86694714, 화합물

생성물 1

HCID 136336869HCID 136336869, 화합물수율 87.4%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
40 °C

실험 절차

To the solution of 1-(6-fluoro-1-methyl-1H-indazol-4-yl)ethanone (900 mg, 4.68 mmol) in EtOH (20 mL) was added hydroxylamine hydrochloride (1.64 g, 23.4 mmol, 5.0 eq.) and NaOAc (3.84 g, 46.8 mmol, 10 eq.). The mixture was stirred at 40° C. overnight, and the solvent was concentrated in vacuo to afford 1-(6-fluoro-1-methyl-1H-indazol-4-yl)ethanone oxime as a white solid (848 mg, 87%). MS (ESI): m/z=208.2 [M+1]+.

후처리

  1. concentrationthe solvent was concentrated in vacuo

출처 및 근거

ORD 기록
ord-b5c1a9679594480c94b066ae6c264968
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637537B2

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