Formic Acid → 5-bromo-4-fluoro-1H-1,3-benzodiazole

HRID 475227노트

반응식

HRID 475227 반응식
[Br:1][C:2]1[C:3]([F:10])=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.[OH-].[Na+].[CH:13](O)=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[NH:8][CH:13]=[N:9][C:4]=2[C:3]=1[F:10]

참가 물질

4

반응물 3

HCID 284Formic AcidHCID 14798Sodium HydroxideHCID 27832034-Bromo-3-fluorobenzene-1,2-diamine

생성물 1

HCID 594744775-bromo-4-fluoro-1H-1,3-benzodiazole수율 92%

실험 절차

A mixture of 142 (25 g, 0.121 mol) and formic acid (75 mL) was heated to reflux for 1.5 h. After the completion of the reaction the reaction was cooled and made basic with 10% NaOH. The resulting solid was filtered and washed with water. Drying overnight under suction afforded 24 g (92%) of 5-bromo-4-fluoro-1H-benzoimidazole (144) as pale yellow solid which was used without further purification.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 1.5 h
  3. customAfter the completion of the reaction the reaction
  4. temperaturewas cooled
  5. filtrationThe resulting solid was filtered
  6. washwashed with water
  7. customDrying overnight under suction

출처 및 근거

ORD 기록
ord-f1583a4b3fe34a2290845f9da677cef6
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637537B2

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