Ammonia → 4-aminomethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
반응식
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[N:7]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]#[N:17])[C:10]=2[CH:9]=[N:8]1.N>CO.[Ni]>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[N:7]1[C:15]2[C:10](=[C:11]([CH2:16][NH2:17])[CH:12]=[CH:13][CH:14]=2)[CH:9]=[N:8]1참가 물질
5
실험 절차
To a solution of 198 (430 mg, 1.89 mmol) in a 7N solution of NH3 in MeOH (20 mL) was added Raney nickel (50 mg), and the mixture was stirred under hydrogen (1 atm) at RT overnight. The Raney nickel was removed by filtration. The filtrate was concentrated to afford 340 mg (79%) of (1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl) methanamine (199) as yellow syrup: MS (ESI) m/z=232.2 [M+1]+.
후처리
- customThe Raney nickel was removed by filtration
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-5d1261c659a34763994c07971a5d2b95
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08637537B2
반응 노트
불러오는 중…