6-Fluoro-1H-indole-4-carbonitrile → HCID 71699932, 화합물
반응식
[F:1][C:2]1[CH:3]=[C:4]([C:11]#[N:12])[C:5]2[CH:6]=[CH:7][NH:8][C:9]=2[CH:10]=1>N.CO.[Ni]>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[C:4]([CH2:11][NH2:12])[CH:3]=1참가 물질
5
실험 절차
To a solution of 226 (588 mg, 3.68 mmol) in 7N NH3 in MeOH (20 mL) was added Raney nickel (20 mg), and then the reaction was stirred under hydrogen (1 atm.) at RT overnight. The dark mixture was filtered and the filtrate was concentrated in vacuo to afford 500 mg (85%) of (6-fluoro-1H-indol-4-yl)methanamine (228) as white solid: MS (ESI) m/z=148.1 [M−16]+.
후처리
- filtrationThe dark mixture was filtered
- concentrationthe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-550e19c3b722438d90e46839d6b385e5
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08637537B2
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