HCID 58403540, 화합물 → (3-methyl-1H-indol-4-yl)methanamine

HRID 475268노트

반응식

HRID 475268 반응식
[CH3:1][C:2]1[C:10]2[C:9]([C:11]#[N:12])=[CH:8][CH:7]=[CH:6][C:5]=2[NH:4][CH:3]=1>N.CO.[Ni]>[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[CH2:11][NH2:12])[NH:4][CH:3]=1

참가 물질

5

반응물 1

HCID 58403540HCID 58403540, 화합물

생성물 1

HCID 83815702(3-methyl-1H-indol-4-yl)methanamine수율 97.5%

시약·촉매·용매 3

HCID 935Nickel촉매HCID 222Ammonia용매HCID 887Methanol용매

실험 절차

To a solution of 232 (200 mg, 1.28 mmol) in 7 N NH3 in MeOH (10 mL) was added Raney nickel (20 mg) and the solution was stirred under hydrogen (1 atm.) at RT overnight. The dark mixture was filtered and the filtrate was concentrated under reduced pressure to afford 200 mg (91%) (3-methyl-1H-indol-4-yl)methanamine (234) as white solid: MS (ESI) m/z=144.3 [M−16]+.

후처리

  1. filtrationThe dark mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f8a1291dc47249ef90b568a104b0f5a9
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637537B2

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