6-chloro-1H-indole-5-carbonitrile → HCID 82408684, 화합물
반응식
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][C:3]=1[C:11]#[N:12]>CO.N.[Ni]>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][C:3]=1[CH2:11][NH2:12]참가 물질
5
실험 절차
To a solution of 242 (43 mg, 0.24 mmol) in MeOH (10 mL) and 7M NH3 in MeOH (5 mL) was added Raney nickel and the reaction mixture was stirred vigorously under hydrogen (1 atm.) at RT for 3 h. The reaction mixture was filtered through a pad of Celite® and concentrated under reduced pressure to afford (6-chloro-1H-indol-5-yl)methanamine (244) as pale oil: MS (ESI)=164.1 [M−NH2]+.
후처리
- filtrationThe reaction mixture was filtered through a pad of Celite®
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-92e38107ab864bb88001239756bb8c64
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08637537B2
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