Water → 2-Cyclopropylethyl methanesulfonate

HRID 475551

반응식

HRID 475551 반응식
[CH:1]1([CH2:4][CH2:5][OH:6])[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:14][S:15](Cl)(=[O:17])=[O:16].O>C(OCC)(=O)C>[CH3:14][S:15]([O:6][CH2:5][CH2:4][CH:1]1[CH2:3][CH2:2]1)(=[O:17])=[O:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 1376422-Cyclopropylethan-1-ol

생성물 1

HCID 145578092-Cyclopropylethyl methanesulfonate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A 0.5 g quantity of 2-cyclopropylethanol and 3.1 ml of triethylamine were dissolved in 10 ml of ethyl acetate, and 0.75 ml of methanesulfonyl chloride was added with ice-cooling and stirring. After stirring for 30 minutes, water was added to the reaction mixture and extraction was performed. The organic layer was washed with water twice and concentrated by removing the solvent under reduced pressure to give 1 g of pale yellow oily 2-cyclopropylethyl methanesulfonate.

후처리

  1. temperaturecooling
  2. stirringAfter stirring for 30 minutes
  3. washThe organic layer was washed with water twice
  4. concentrationconcentrated
  5. customby removing the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-9027ce4a434f4a6d8f1ff10f40755bef
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637559B2

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