Pivalaldehyde → N-neopentylidene-L-alanine ethyl ester

HRID 47595

반응식

HRID 47595 반응식
[CH2:1]([O:3][C:4](=[O:8])[C@H:5]([CH3:7])[NH2:6])[CH3:2].[O-]S([O-])(=O)=O.[Mg+2].[CH:15](=O)[C:16]([CH3:19])([CH3:18])[CH3:17]>C(Cl)Cl>[CH2:1]([O:3][C:4](=[O:8])[C@H:5]([CH3:7])[N:6]=[CH:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH3:2]

참가 물질

5

반응물 3

HCID 12417PivalaldehydeHCID 24083Sulfuric acid magnesium salt (1:1)HCID 76507L-Alanine ethyl ester

생성물 1

HCID 11412788N-neopentylidene-L-alanine ethyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

Step-2. L-Alanine ethyl ester from step-1 (9 g) was dissolved in 150 ml anhydrous CH2Cl2. The solution was cooled to 0° C. MgSO4 (10.17 g) was added to the solution followed by addition of pivalaldehyde (6.95 g). The reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction mixture was filtered and the filtrate was evaporated to give 11.2 g of N-neopentylidene-L-alanine ethyl ester. The product was used for next step without further purification. MS: 186 (MH+).

후처리

  1. temperatureto warm to room temperature
  2. filtrationThe reaction mixture was filtered
  3. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-ab9b76fdbc7743159f62fc351f2ad4f3
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699888B2

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