Pivalaldehyde → N-neopentylidene-L-alanine ethyl ester
반응식
[CH2:1]([O:3][C:4](=[O:8])[C@H:5]([CH3:7])[NH2:6])[CH3:2].[O-]S([O-])(=O)=O.[Mg+2].[CH:15](=O)[C:16]([CH3:19])([CH3:18])[CH3:17]>C(Cl)Cl>[CH2:1]([O:3][C:4](=[O:8])[C@H:5]([CH3:7])[N:6]=[CH:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH3:2]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
Step-2. L-Alanine ethyl ester from step-1 (9 g) was dissolved in 150 ml anhydrous CH2Cl2. The solution was cooled to 0° C. MgSO4 (10.17 g) was added to the solution followed by addition of pivalaldehyde (6.95 g). The reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction mixture was filtered and the filtrate was evaporated to give 11.2 g of N-neopentylidene-L-alanine ethyl ester. The product was used for next step without further purification. MS: 186 (MH+).
후처리
- temperatureto warm to room temperature
- filtrationThe reaction mixture was filtered
- customthe filtrate was evaporated
출처 및 근거
- ORD 기록
- ord-ab9b76fdbc7743159f62fc351f2ad4f3
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06699888B2
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