Methyl acetoacetate → HCID 178463089, 화합물

HRID 47618노트

반응식

HRID 47618 반응식
C(O)(=O)C(O)=O.[CH2:7]([NH:9][NH2:10])[CH3:8].C(N(CC)CC)C.[C:18](OC)(=[O:23])[CH2:19][C:20]([CH3:22])=O>C1(C)C=CC=CC=1>[CH2:7]([N:9]1[C:18]([OH:23])=[CH:19][C:20]([CH3:22])=[N:10]1)[CH3:8]

참가 물질

5

반응물 3

HCID 7757Methyl acetoacetateHCID 8471TriethylamineHCID 96181Hydrazine, ethyl-, ethanedioate (1:1)

생성물 1

HCID 178463089HCID 178463089, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A suspension of 3.9 g of ethyl hydrazine oxalate and 3.6 ml of triethylamine in 80 ml of toluene was stirred at room temperature for 15 min. 2.8 ml of methyl acetoacetate was added and the mixture was azeotroped for 1.5 h. The mixture was evaporated and the residue was purified by flash chromatography on silica gel using dichloromethane/methanol (97:3) for the elution to give 3.1 g of 2-ethyl-5-methyl-2H-pyrazol-3-ol as an orange solid.

후처리

  1. customthe mixture was azeotroped for 1.5 h
  2. customThe mixture was evaporated
  3. customthe residue was purified by flash chromatography on silica gel
  4. washfor the elution

출처 및 근거

ORD 기록
ord-dc9105b2b9334599b979c7551c1748dd
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699887B2

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