Methyl acetoacetate → HCID 178463089, 화합물

HRID 47628노트

반응식

HRID 47628 반응식
C(O)(=O)C(O)=O.[CH2:7]([NH:9][NH2:10])[CH3:8].C(N(CC)CC)C.[C:18](OC)(=[O:23])[CH2:19][C:20]([CH3:22])=O>C1(C)C=CC=CC=1>[CH2:7]([N:9]1[C:18]([OH:23])=[CH:19][C:20]([CH3:22])=[N:10]1)[CH3:8]

참가 물질

5

반응물 3

HCID 7757Methyl acetoacetateHCID 8471TriethylamineHCID 96181Hydrazine, ethyl-, ethanedioate (1:1)

생성물 1

HCID 178463089HCID 178463089, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A suspension of 23 g of ethyl hydrazine oxalate and 22 ml of triethylamine in 500 ml of toluene was stirred at room temperature for 15 minutes. 17 ml of methyl acetoacetate was added and the mixture was azeotroped for 1.5 hours. The mixture was evaporated and the residue was purified by flash chromatography on silica gel using dichloromethane/methanol (97:3) for the elution to give 19 g of 2-ethyl-5-methyl-2H-pyrazol-3-ol as an orange solid.

후처리

  1. customthe mixture was azeotroped for 1.5 hours
  2. customThe mixture was evaporated
  3. customthe residue was purified by flash chromatography on silica gel
  4. washfor the elution

출처 및 근거

ORD 기록
ord-3e722a6946a544cca7bd5c0d21f6cef4
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699887B2

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