O1CCCC1.[CH2:6]([SH:8])[CH3:7].C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][C:17]1[C:18]([Cl:31])=[C:19]([CH:24]=[CH:25][C:26]=1[S:27]([CH3:30])(=[O:29])=[O:28])[C:20]([O:22][CH3:23])=[O:21]>C(Cl)(Cl)Cl>[Cl:31][C:18]1[C:17]([CH2:16][S:8][CH2:6][CH3:7])=[C:26]([S:27]([CH3:30])(=[O:29])=[O:28])[CH:25]=[CH:24][C:19]=1[C:20]([O:22][CH3:23])=[O:21]To 100 ml of tetrahydrofuran, 1.3 g of ethanethiol and 1.5 g of potassium carbonate and then 4.4 g of methyl 3-bromomethyl-2-chloro-4-methanesulfonylbenzoate were added, and the mixture was stirred for 1 day at room temperature. Then, the mixture was stirred further for 1 hour at a temperature of from 50° to 60° C. After cooling, chloroform was added thereto, and the mixture was washed with a dilute potassium carbonate aqueous solution. The chloroform layer was separated and dried. Then, the solvent was distilled off to obtain 4.1 g of methyl 2-chloro-3-ethylthiomethyl-4-methanesulfonylbenzoate as an oily substance.
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