1-Acetyl-4-(4-nitrophenyl)piperazine → 1-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one

HRID 476561

반응식

HRID 476561 반응식
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>[Ni].C(O)C>[C:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

참가 물질

4

반응물 1

HCID 28651491-Acetyl-4-(4-nitrophenyl)piperazine

생성물 1

HCID 7362691-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

A suspension of 4-acetyl-1-(4-nitrophenyl)piperazine [C. A., 67, P101031Z] (30 g, 0.12 mole) and Raney nickel (2.5 g) in ethanol (500 ml) was hydrogenated at 60 psi (414 kPa) and 40° for 6 hours followed by 18 hours at room temperature. The catalyst was subsequently removed by filtration, the solvent removed under reduced pressure and the residue crystallized from ethyl acetate to yield the title compound, m.p. 129°-130° (18.4 g, 71%), which was used directly in the next stage.

후처리

  1. customThe catalyst was subsequently removed by filtration
  2. customthe solvent removed under reduced pressure
  3. customthe residue crystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-48c587c122724d43b4582d3b03fd9db0
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04885294

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