Formamide → HCID 18409955, 화합물

HRID 476590노트

반응식

HRID 476590 반응식
S(O)(O)(=O)=O.[NH2:6][C:7]1[N:8]=[C:9]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:21][CH2:22][CH2:23][CH3:24])[NH:10][C:11](=[O:14])[C:12]=1[NH2:13].S(=O)(=O)(O)O.[CH:30](N)=O>>[CH2:22]([O:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:9]1[N:8]=[C:7]2[C:12](=[N:13][CH:30]=[N:6]2)[C:11](=[O:14])[N:10]=1)[CH2:23][CH3:24]

참가 물질

4

반응물 3

HCID 713FormamideHCID 1118Sulfuric AcidHCID 1363645694,5-Diamino-2-(propoxyphenyl)pyrimidin-6-one sulphate

생성물 1

HCID 18409955HCID 18409955, 화합물

실험 절차

A stirred mixture of 4,5-diamino-2-(2-propoxyphenyl)pyrimidin-6-one sulphate (1.5 g) (prepared by the addition of concentrated sulphuric acid to an ethanolic solution of the free base) and formamide (15 ml) was heated in an oil bath (temp. 190°-200° C.) for 70 minutes. When cool the mixture was filtered and the collected solid was washed with ethanol to give a crude product (1.1 g), m.p. 254°-259° C., which was recrystallised from ethanol to give the title compound, 0.72 g, m.p. 263°-265° C.

후처리

  1. temperaturewas heated in an oil bath (temp. 190°-200° C.) for 70 minutes
  2. temperatureWhen cool the mixture
  3. filtrationwas filtered
  4. washthe collected solid was washed with ethanol
  5. customto give a crude product (1.1 g), m.p. 254°-259° C., which
  6. customwas recrystallised from ethanol

출처 및 근거

ORD 기록
ord-98875e5283ea47cd9992140358bd2d55
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04885301

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