Flavanone → 3(3-Acetylaminobenzylidene)-flavanone

HRID 476606

반응식

HRID 476606 반응식
[O:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[CH2:3][CH:2]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[C:18]([NH:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH:25]=O)(=[O:20])[CH3:19]>N1CCCCC1.C(Cl)(Cl)Cl>[C:18]([NH:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH:25]=[C:3]1[C:4](=[O:5])[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[O:1][CH:2]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:20])[CH3:19]

참가 물질

5

반응물 2

HCID 10251FlavanoneHCID 256849N-(3-formylphenyl)acetamide

생성물 1

HCID 544909013(3-Acetylaminobenzylidene)-flavanone

시약·촉매·용매 2

HCID 8082Piperidine촉매HCID 6212Chloroform용매

실험 절차

A solid mixture of 9 g flavanone, 7.2 g 3-acetylaminobenzaldehyde and 5 drops piperidine is heated at 150°-160° C. for 3 hours. After allowing to cool, the crude brown glass is dissolved in chloroform and eluted from silicagel with chloroform. The pale yellow oil, obtained on evaporation of the solvent is crystallized from hexane and ethyl acetate to give 3(3-acetylaminobenzylidene)-flavanone as a cream coloured solid; m.p. 172°-173° C.

후처리

  1. temperatureis heated at 150°-160° C. for 3 hours
  2. temperatureto cool
  3. washeluted from silicagel with chloroform
  4. customThe pale yellow oil, obtained on evaporation of the solvent
  5. customis crystallized from hexane and ethyl acetate

출처 및 근거

ORD 기록
ord-a9263f90fdaa436fa0e4abe4c0c2c154
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04885298

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