Hydrochloric Acid → N-[2-(Cyclohexyloxy)phenyl]methanesulfonamide

HRID 476735

반응식

HRID 476735 반응식
[CH:1]1([O:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[NH2:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:15][S:16](Cl)(=[O:18])=[O:17].Cl>N1C=CC=CC=1>[CH:1]1([O:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[NH:10][S:16]([CH3:15])(=[O:18])=[O:17])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 31297Methanesulfonyl chlorideHCID 14771305HCID 14771305, 화합물

생성물 1

HCID 14771306N-[2-(Cyclohexyloxy)phenyl]methanesulfonamide수율 89.4%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To 20 ml of a pyridine solution containing 2.7 g of 2-cyclohexyloxyaniline was added dropwise 1.8 g of methanesulfonyl chloride under ice cooling with stirring. After completion of the addition, the mixture was stirred at room temperature for 2 hours. The reaction solution was poured into ice water and made acidic with dilute hydrochloric acid. The crystals which formed were collected by filtration, washed with water and dried to give 3.8 g of the crude crystals, which were then recrystallized from ethanol-n hexane to give 3.4 g of N-(2-cyclohexyloxyphenyl)methanesulfonamide.

후처리

  1. additionAfter completion of the addition
  2. stirringthe mixture was stirred at room temperature for 2 hours
  3. customThe crystals which formed
  4. filtrationwere collected by filtration
  5. washwashed with water
  6. customdried
  7. customto give 3.8 g of the crude crystals, which
  8. customwere then recrystallized from ethanol-n hexane

출처 및 근거

ORD 기록
ord-d60f411f1bd84b318eff2566602610b7
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04885367

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