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Triethylamine → 7-(4-Chlorobutyramido)-2,3,5,6,7,8-hexahydronaphtho[2,3-b]furan

HRID 476768
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반응식

HRID 476768 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][C:5](Cl)=[O:6].Cl.[NH2:9][CH:10]1[CH2:22][C:21]2[C:13](=[CH:14][C:15]3[CH2:19][CH2:18][O:17][C:16]=3[CH:20]=2)[CH2:12][CH2:11]1.C(N(CC)CC)C>C1C=CC=CC=1.O>[Cl:1][CH2:2][CH2:3][CH2:4][C:5]([NH:9][CH:10]1[CH2:22][C:21]2[C:13](=[CH:14][C:15]3[CH2:19][CH2:18][O:17][C:16]=3[CH:20]=2)[CH2:12][CH2:11]1)=[O:6]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 783704-Chlorobutyryl chlorideHCID 19838440HCID 19838440, 화합물

생성물 1

HCID 198384557-(4-Chlorobutyramido)-2,3,5,6,7,8-hexahydronaphtho[2,3-b]furan

시약·촉매·용매 2

HCID 241Benzene용매HCID 962Water용매

실험 절차

4.2 g of 4-chlorobutyryl chloride are added at room temperature to a mixture of 5 g of the compound of Example 2 and 4.2 g of triethylamine in 60 ml of benzene. After 1 hour at room temperature, the medium is diluted with water and filtered and the aqueous phase is extracted with benzene. The filtrate and the precipitate are combined and the benzene is evaporated off under vacuum. The dry residue is solidified in ether.

후처리

  1. filtrationfiltered
  2. extractionthe aqueous phase is extracted with benzene
  3. customthe benzene is evaporated off under vacuum

출처 및 근거

ORD 기록
ord-9218debab23b41eb9f63aad566202f4b
출처 데이터셋
uspto-grants-1989_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04885373

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