(5-Aminopentyl)diethylamine → P,P-bis(2,2-dimethyl-1-aziridinyl)-N-(5-diethylamino-1-pentyl)-phosphinic amide

HRID 476851

반응식

HRID 476851 반응식
[CH3:1][C:2]1([CH3:13])[CH2:4][N:3]1[P:5](Cl)([N:7]1[CH2:9][C:8]1([CH3:11])[CH3:10])=[O:6].[CH2:14]([N:16]([CH2:23][CH3:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])[CH3:15]>C1COCC1>[CH3:1][C:2]1([CH3:13])[CH2:4][N:3]1[P:5]([N:7]1[CH2:9][C:8]1([CH3:11])[CH3:10])(=[O:6])[NH:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][N:16]([CH2:23][CH3:24])[CH2:14][CH3:15]

참가 물질

4

반응물 2

HCID 4584949(5-Aminopentyl)diethylamineHCID 13511140P,P-bis(2,2-dimethyl-1-aziridinyl)phosphinyl chloride

생성물 1

HCID 19836605P,P-bis(2,2-dimethyl-1-aziridinyl)-N-(5-diethylamino-1-pentyl)-phosphinic amide수율 90%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

In a similar manner 0.025 moles of P,P-bis(2,2-dimethyl-1-aziridinyl)phosphinoyl chloride in about 170 mL of THF are treated by dropwise addition with 0.026 moles of 5-diethylaminopentylamine in 25 mL of THF, stirred for several hours at ambient temperature, filtered, concentrated by rotary evaporation and vacuum distilled to yield about 90% pure P,P-bis(2,2-dimethyl-1-aziridinyl)-N-(5-diethylamino-1-pentyl)-phosphinic amide.

후처리

  1. filtrationfiltered
  2. concentrationconcentrated by rotary evaporation and vacuum
  3. distillationdistilled

출처 및 근거

ORD 기록
ord-9aef35d6daf64598af0ba4a421975c18
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886790

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