Hydrazine hydrate (1:1) → 2-Hydrazinyl-3-(trifluoromethyl)pyridine
반응식
Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1.O.[NH2:13][NH2:14]>C(O)C>[F:9][C:8]([F:11])([F:10])[C:7]1[C:2]([NH:13][NH2:14])=[N:3][CH:4]=[CH:5][CH:6]=1참가 물질
4
실험 절차
A solution of 200 g of 2-chloro-3-trifluoromethylpyridine in 500 ml of ethanol and 300 ml of hydrazine hydrate is heated under reflux for 6 hours. The solution is then concentrated in vacuo and, after cooling, the crystalline residue is then taken up with water, filtered off, washed with water and dried to give 145 g of 3-trifluoromethyl-2-hydrazinopyridine in the form of crystals melting at 72° C.
후처리
- temperatureunder reflux for 6 hours
- concentrationThe solution is then concentrated in vacuo
- temperatureafter cooling
- filtrationfiltered off
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-7ac3c1c437ee4f2b962516c2993db7b9
- 출처 데이터셋
- uspto-grants-1989_12
- 특허 번호
- US04886805
반응 노트
불러오는 중…