Carbon Disulfide → HCID 178506204, 화합물

HRID 476903노트

반응식

HRID 476903 반응식
[C:1](=[S:3])=S.[F:4][C:5]([F:15])([F:14])[C:6]1[C:7]([NH:12][NH2:13])=[N:8][CH:9]=[CH:10][CH:11]=1>N1C=CC=CC=1>[SH:3][C:1]1[N:8]2[CH:9]=[CH:10][CH:11]=[C:6]([C:5]([F:15])([F:14])[F:4])[C:7]2=[N:12][N:13]=1

참가 물질

4

반응물 2

HCID 6348Carbon DisulfideHCID 27777762-Hydrazinyl-3-(trifluoromethyl)pyridine

생성물 1

HCID 178506204HCID 178506204, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

16 ml of carbon disulfide are added dropwise at room temperature, with stirring, to a suspension of 40 g of 3-trifluoromethyl-2-hydrazinopyridine, prepared in Example 12, in 75 ml of pyridine. When the additioon is complete, stirring is continued for 15 minutes at room temperature and the reaction mixture is then heated under reflux for 5 hours. After cooling, the medium is concentrated in vacuo and water is then added. The solid residue obtained is filtered off, washed with water and dried to give 40 g of 3-mercapto-8-trifluoromethyl-1,2,4-triazolo(4,3-a)pyridine in the form of crystals melting at 236° C.

후처리

  1. temperaturethe reaction mixture is then heated
  2. temperatureunder reflux for 5 hours
  3. temperatureAfter cooling
  4. concentrationthe medium is concentrated in vacuo and water
  5. additionis then added
  6. customThe solid residue obtained
  7. filtrationis filtered off
  8. washwashed with water
  9. customdried

출처 및 근거

ORD 기록
ord-a55edcc8dff24222a6a3944319a25426
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886805

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