Phosphorus oxychloride → 6-Imino-1,3-dimethyl-5-dimethylaminomethylene-5,6-dihydrouracil hydrochloride
반응식
[NH2:1][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[CH:3]=1.P(Cl)(Cl)([Cl:14])=O>CN(C)C=O>[ClH:14].[NH:1]=[C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]1=[CH:4][N:5]([CH3:10])[CH3:6]참가 물질
4
실험 절차
20 g (129 mmol) of 6-amino-1,3-dimethyluracil was suspended in 550 ml of dimethylformamide. 216 g of phosphorus oxychloride was added to the suspension at a temperature below 20° C., and the reaction mixture was stirred for 30 minutes. The resulting precipitate was filtered off and washed with acetone to give 6-imino-1,3-dimethyl-5-dimethylaminomethylene-5,6-dihydrouracil hydrochloride (compound 1) in a 95% yield. The product may also be used in the following reaction without further purification.
후처리
- filtrationThe resulting precipitate was filtered off
- washwashed with acetone
출처 및 근거
- ORD 기록
- ord-c00c826eb76b43c4a2dcc754487c2286
- 출처 데이터셋
- uspto-grants-1989_12
- 특허 번호
- US04886807
반응 노트
불러오는 중…