Formamide → 5-amino-1,3-dimethyl-1H,2H,3H,4H-[1,3]diazino[4,5-d]pyrimidine-2,4-dione

HRID 476913노트

반응식

HRID 476913 반응식
[NH2:1][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[C:12]#[N:13].[CH:14]([NH2:16])=O>O>[NH2:13][C:12]1[N:16]=[CH:14][N:1]=[C:2]2[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=12

참가 물질

4

반응물 2

HCID 713FormamideHCID 13296989HCID 13296989, 화합물

생성물 1

HCID 124906845-amino-1,3-dimethyl-1H,2H,3H,4H-[1,3]diazino[4,5-d]pyrimidine-2,4-dione수율 58%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

0.3 g (1.7 mmol) of 6-amino-5-cyano-1,3-dimethyluracil was added to 2 ml of formamide followed by refluxing for 2 hours. 10 ml of water was added to the solution and the crystalline precipitate was filtered off. The crude product was recrystallized from methanol to give 0.2 g of 5-amino-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4-dione (compound 9) in a 58% yield.

후처리

  1. temperatureby refluxing for 2 hours
  2. filtrationthe crystalline precipitate was filtered off
  3. customThe crude product was recrystallized from methanol

출처 및 근거

ORD 기록
ord-378c039ac0b149548c2c17594842b502
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886807

반응 노트

불러오는 중…