Hydrochloric Acid → 12-(Methanesulfonyl)-3-methoxy-5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquinolino[2,1-g][1,6]naphthyridine--hydrogen chloride (1/1)
반응식
C(O)(=O)C.[CH3:5][O:6][C:7]1[CH:24]=[CH:23][C:22]2[C@H:21]3[N:12]([CH2:13][C@@H:14]4[C@H:19]([CH2:20]3)[N:18]([S:25]([CH3:28])(=[O:27])=[O:26])[CH2:17][CH2:16][CH2:15]4)[CH2:11][CH2:10][C:9]=2[CH:8]=1.[ClH:29]>>[ClH:29].[CH3:5][O:6][C:7]1[CH:24]=[CH:23][C:22]2[C@H:21]3[N:12]([CH2:13][C@@H:14]4[C@H:19]([CH2:20]3)[N:18]([S:25]([CH3:28])(=[O:27])=[O:26])[CH2:17][CH2:16][CH2:15]4)[CH2:11][CH2:10][C:9]=2[CH:8]=1참가 물질
3
반응물 2
생성물 1
실험 절차
(8aR,12aS,13aS)-3-methoxy-12-methanesulfonyl-5,6,8a,9,10,11,12,12a,13,13a-decahydro-8H-isoquino[2,1-g][1,6]naphthyridine acetate (1.0 g) is dissolved in 50 ml 5N aqueous hydrochloric acid, and the solution evaporated to dryness. The product is suspended in ethyl acetate and filtered, air dried and recrystallized from methanol/acetone to yield (8aR,12aS,13aS)-3-methoxy-12-methanesulfonyl-5,6,8a,9,10,11,12,12a,13,13a-decahydro-8H-isoquino[2,1-g][1,6]naphthyridine hydrochloride.