Methyl iodide → 4-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanol

HRID 476959

반응식

HRID 476959 반응식
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][NH:7][CH:8]2[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[C:17](=O)([O-])[O-].[K+].[K+].CI>CN(C)C=O>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]([CH3:17])[CH:8]2[CH2:9][CH2:10][CH:11]([OH:14])[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 136706584-(4-Chloro-benzylamino)-cyclohexanol

생성물 1

HCID 136706604-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanol

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

7.2 g (30 mMol) of 4-[N-(4-chloro-benzyl)-amino]-cyclohexanol are dissolved in 30 ml of dimethyl-formamide, and after the addition of 2.2 g (16 mMol) of potassium carbonate, 4.26 g (30 mMol) of methyliodide are added dropwise. When the slightly exothermic reaction has ended, the mixture is concentrated by evaporation, mixed with water and extracted with chloroform. The concentrated extracts are chromatographed on silica gel to purify them (eluant; methylene chloride/methanol=20/1).

후처리

  1. additionare added dropwise
  2. customWhen the slightly exothermic reaction
  3. concentrationthe mixture is concentrated by evaporation
  4. additionmixed with water
  5. extractionextracted with chloroform
  6. customThe concentrated extracts are chromatographed on silica gel
  7. customto purify them (eluant; methylene chloride/methanol=20/1)

출처 및 근거

ORD 기록
ord-ea0f263269c04da98b88a92206933b76
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886812

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