Acetic Anhydride → Ethyl 2-[(2,2,3-trifluoro-1,4-benzodioxan-5-yl)methylene]-4-acetoxy-acetoacetate

HRID 476972노트

반응식

HRID 476972 반응식
C(N=C[C:7]1([F:19])[C:12]([F:14])([F:13])[O:11][C:10]2[CH:15]=[CH:16][CH:17]=[CH:18][C:9]=2[O:8]1)CCC.[C:20]([O:23][CH2:24][C:25](=[O:32])[CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])(=[O:22])[CH3:21].[C:33](OC(=O)C)(=O)C>>[F:14][C:12]1([F:13])[O:11][C:10]2[CH:15]=[CH:16][CH:17]=[C:18]([CH:33]=[C:26]([C:25]([CH2:24][O:23][C:20](=[O:22])[CH3:21])=[O:32])[C:27]([O:29][CH2:30][CH3:31])=[O:28])[C:9]=2[O:8][CH:7]1[F:19]

참가 물질

4

반응물 3

HCID 7918Acetic AnhydrideHCID 11480907Ethyl 4-acetoxyacetoacetateHCID 86743569Butyliminomethyl-2,2,3-trifluoro-1,4-benzodioxane

생성물 1

HCID 53756174Ethyl 2-[(2,2,3-trifluoro-1,4-benzodioxan-5-yl)methylene]-4-acetoxy-acetoacetate

실험 절차

50 mmol of 5-(butyliminomethyl-2,2,3-trifluoro-1,4-benzodioxane and 50 mmol of ethyl 4-acetoxy-acetoacetate are stirred in 80 ml of acetic anhydride for 24 hours. The mixture is hydrolyzed with about 1 l of ice-water and the oil which has separated out is separated off, taken up in methylene chloride, dried and used as the crude product.

후처리

  1. customthe oil which has separated out
  2. customis separated off
  3. customdried

출처 및 근거

ORD 기록
ord-bdfc2d68bac94c4da429bbdc0aa2160f
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886816

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