Epichlorohydrin → 4-Glycidoxy-2-nitroacetanilide
반응식
[CH2:1]([CH:3]1[O:5][CH2:4]1)Cl.[N+:6]([C:9]1[CH:10]=[C:11]([OH:19])[CH:12]=[CH:13][C:14]=1[NH:15][C:16](=[O:18])[CH3:17])([O-:8])=[O:7]>[OH-].[Na+]>[N+:6]([C:9]1[CH:10]=[C:11]([CH:12]=[CH:13][C:14]=1[NH:15][C:16](=[O:18])[CH3:17])[O:19][CH2:1][CH:3]1[O:5][CH2:4]1)([O-:8])=[O:7]참가 물질
4
실험 절차
150 ml of epichlorohydrin are added, at ambient temperature, to a solution of 0.376 mol (73.7 g) of 3-nitro-4-acetylaminophenol in 375 ml of 1.1N sodium hydroxide solution. The reaction medium is left to stand at ambient temperature for 48 hours, with thorough stirring, and the expected product which has precipitated is then filtered off. After drying in vacuo and recrystallisation from benzene, this product melts at 123° C.
후처리
- waitThe reaction medium is left
- customthe expected product which has precipitated
- filtrationis then filtered off
- dry with materialAfter drying in vacuo and recrystallisation from benzene
출처 및 근거
- ORD 기록
- ord-6d1a094025774fb68477135b6ab6ba48
- 출처 데이터셋
- uspto-grants-1989_12
- 특허 번호
- US04888025
반응 노트
불러오는 중…