Water → HCID 11791018, 화합물
반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11](=[O:12])[C:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=3[CH2:8][O:7][C:6]=2[CH:17]=1.[BH4-].[Na+].O>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:11]([OH:12])[C:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=3[CH2:8][O:7][C:6]=2[CH:17]=1참가 물질
5
실험 절차
To a solution of 2.0 g of 3-fluoro-6,11-dihydrodibenz[b,e]oxepin-11-one in 20 ml of methanol is added 0.5 g of sodium borohydride with ice-cooling and then the mixture is stirred at the same temperature for 1 hour. The reaction mixture is poured into water and the resultant is extracted with toluene. The extract is washed with water and then dried over magnesium sulfate. Toluene is distilled off to give 1.9 g of 3-fluoro-6,11-dihydrodibenz[b,e]oxepin-11-ol (crystals). Mass spectrum m/z: 230(M+).
후처리
- temperaturecooling
- extractionthe resultant is extracted with toluene
- washThe extract is washed with water
- dry with materialdried over magnesium sulfate
- distillationToluene is distilled off
출처 및 근거
- ORD 기록
- ord-bbee9ad46f224e4590e569f45ad15f0e
- 출처 데이터셋
- uspto-grants-1989_12
- 특허 번호
- US04889858
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