Dimethylformamide → Ethyl 3-fluoro-2-methylbenzoate
반응식
[F:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].CN(C)C=O.C(=O)([O-])[O-].[K+].[K+].[CH2:23](I)[CH3:24]>C1(C)C=CC=CC=1>[F:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([O:7][CH2:23][CH3:24])=[O:6]참가 물질
6
실험 절차
To a solution of 10 g of 3-fluoro-2-methylbenzoic acid [J. Org. Chem., 26, 3208 (1961)]in 300 ml of dimethylformamide are added 30 g of potassium carbonate and 30 g of ethyl iodide and the mixture is stirred at room temperature for 8 hours. After adding 500 ml of toluene, washing with water and a saturated saline solution and drying over magnesium sulfate, the solvent is distilled off under reduced pressure to give 11 g of ethyl 3-fluoro-2-methylbenzoate (oil). Mass spectrum m/z: 182(M+).
후처리
- washwashing with water
- dry with materiala saturated saline solution and drying over magnesium sulfate
- distillationthe solvent is distilled off under reduced pressure
출처 및 근거
- ORD 기록
- ord-e5a800762539454e9188c5139c31b007
- 출처 데이터셋
- uspto-grants-1989_12
- 특허 번호
- US04889858
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