N-bromobutanimide → Ethyl 2-(bromomethyl)-3-fluorobenzoate

HRID 477786노트

반응식

HRID 477786 반응식
[F:1][C:2]1[C:3]([CH3:13])=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6].[Br:14]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[F:1][C:2]1[C:3]([CH2:13][Br:14])=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 14626272Ethyl 3-fluoro-2-methylbenzoate

생성물 1

HCID 14626273Ethyl 2-(bromomethyl)-3-fluorobenzoate수율 82.5%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

To a solution of 11 g of ethyl 3-fluoro-2-methylbenzoate in 300 ml of carbon tetrachloride is added 12 g of N-bromosuccinimide and the mixture is refluxed with heating for 12 hours. After cooling, the mixture is washed with water and a saturated saline solution and dried over magnesium sulfate and the solvent is distilled off under reduced pressure to give 13 g of ethyl 3-fluoro-2-bromomethylbenzoate. Mass spectrum m/z: 262, 260(M+).

후처리

  1. temperaturethe mixture is refluxed
  2. temperaturewith heating for 12 hours
  3. temperatureAfter cooling
  4. washthe mixture is washed with water
  5. dry with materiala saturated saline solution and dried over magnesium sulfate
  6. distillationthe solvent is distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-44272f909ca047aca1e56cdfa6c427f5
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04889858

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