Hydrochloric Acid → HCID 14652622, 화합물

HRID 477833

반응식

HRID 477833 반응식
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:24])=[C:10]([N:14]3[CH2:19][CH2:18][O:17][CH:16]([CH2:20][NH:21]C=O)[CH2:15]3)[C:11]=2[F:13])[C:6](=[O:25])[C:5]([C:26]([OH:28])=[O:27])=[CH:4]1)[CH3:2].[ClH:29].O>CO>[ClH:29].[NH2:21][CH2:20][CH:16]1[CH2:15][N:14]([C:10]2[C:11]([F:13])=[C:12]3[C:7]([C:6](=[O:25])[C:5]([C:26]([OH:28])=[O:27])=[CH:4][N:3]3[CH2:1][CH3:2])=[CH:8][C:9]=2[F:24])[CH2:19][CH2:18][O:17]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 146526021-Ethyl-6,8-difluoro-7-[2-(formylaminomethyl)morpholino]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

생성물 1

HCID 14652622HCID 14652622, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 500 mg of 1-ethyl-6,8-difluoro-7-[2-(formylaminomethyl)morpholino]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 1 ml of concentrated hydrochloric acid, 2 ml of water and 10 ml of methanol is refluxed for 1.5 hours. The reaction mixture is concentrated under reduced pressure. The obtained crystals are washed with acetone, collected by filtration and recrystallized from dimethylformamide to give 7-[2-(aminomethyl)morpholino]-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride, melting at 276°-278° C. with decomposition.

후처리

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. washThe obtained crystals are washed with acetone
  3. filtrationcollected by filtration
  4. customrecrystallized from dimethylformamide

출처 및 근거

ORD 기록
ord-1875382aeec84616b2a292f5272f54b6
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04889857

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