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Acetone → Methyl 7-[[5-(4-acetyl-3-methoxy-2-propylphenoxy)pentyl]oxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate

HRID 478024
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인쇄 미리보기

반응식

HRID 478024 반응식
[C:1]([C:4]1[CH:33]=[CH:32][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:28]=[CH:27][C:18]3[CH2:19][CH2:20][CH:21]([C:23]([O:25][CH3:26])=[O:24])[O:22][C:17]=3[C:16]=2[CH2:29][CH2:30][CH3:31])=[C:6]([CH2:34][CH2:35][CH3:36])[C:5]=1[OH:37])(=[O:3])[CH3:2].[CH3:38]C(C)=O.S(OC)(OC)(=O)=O>[OH-].[K+]>[C:1]([C:4]1[CH:33]=[CH:32][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:28]=[CH:27][C:18]3[CH2:19][CH2:20][CH:21]([C:23]([O:25][CH3:26])=[O:24])[O:22][C:17]=3[C:16]=2[CH2:29][CH2:30][CH3:31])=[C:6]([CH2:34][CH2:35][CH3:36])[C:5]=1[O:37][CH3:38])(=[O:3])[CH3:2]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 180AcetoneHCID 6497Dimethyl SulfateHCID 135378702-Carbomethoxy-7-[5-(2-n-propyl-3-hydroxy-4-acetylphenoxy)pentoxy]-8-n-propylchroman

생성물 1

HCID 14722866Methyl 7-[[5-(4-acetyl-3-methoxy-2-propylphenoxy)pentyl]oxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate

시약·촉매·용매 1

HCID 14797Potassium Hydroxide용매

반응 조건

온도
40 °C

실험 절차

Methyl 7-[[5-(4-acetyl-3-hydroxy-2-propylphenoxy)pentyl]oxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylate (1 mMol), prepared as described in U.S. Pat. No. 4,565,882, was dissolved in acetone containing 2.5 equivalents of potassium hydroxide and 3 equivalents of dimethyl sulfate. The mixture was heated at 40° C. for 10 hours and then cooled; the solvent was removed in vacuo and the residue partitioned between ethyl acetate and water. The organic layer was separated and dried over magnesium sulfate. Evaporation of the volatiles in vacuo afforded the methyl ether.

후처리

  1. temperaturecooled
  2. customthe solvent was removed in vacuo
  3. customthe residue partitioned between ethyl acetate and water
  4. customThe organic layer was separated
  5. dry with materialdried over magnesium sulfate
  6. customEvaporation of the volatiles in vacuo

출처 및 근거

ORD 기록
ord-f81d366078034e35837fc799910c0f83
출처 데이터셋
uspto-grants-1989_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04889871

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